When you have finished you can save the slideshow to disc, hardware, portable device, as an image sequence or Flash file, or if you like you can upload it, as well as create a DVD movie or data disc of your slideshow. Additionally, you can record a narration, preview the slideshow, save the current frame as an image, shuffle clips, and apply multiple clips effects such as black and white, negative, sepia, oil painting. Next, you specify what type of transitions you need fade, reveal, wipe, circle, heart, or diamond. Once the framework of your slideshow is in place you can add effects such as altering brightness, crop, rotate, speed, and zoom. You begin by importing photographs and or media files by either ‘drag and drop’ method or via the file browser. Why not create a slideshow with your pictures? PhotoStage Free Photo Slideshow makes showing off your pictures easy and fun to create, thanks to clean and intuitive interface. Most of us take thousands of images, but tend not to do much with them.
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Hypertension is among the most prevalent of these vascular risk factors, occurring in nearly one-third of adults and two-thirds of older adults worldwide ( Mills et al., 2016). Specifically, there is ongoing debate as to whether vascular risk factors contribute to the deposition of the neuritic plaques and neurofibrillary tangles (NFTs) that represent the pathological hallmarks of Alzheimer’s dementia ( Hyman et al., 2012), lead to cerebrovascular changes that in turn lower the threshold for the clinical expression of Alzheimer’s dementia pathology, or operate through both mechanisms ( Zlokovic, 2011 Chui et al., 2012). However, the role of vascular risk factors in Alzheimer’s dementia pathophysiology remains unclear. Hypertension is believed to increase susceptibility to Alzheimer’s dementia ( Skoog et al., 1996 Launer et al., 2000 Walker et al., 2017). Circle of Willis atherosclerosis may be an important point of convergence between vascular risk factors, cerebrovascular changes and Alzheimer’s disease neuropathology. These results suggest that hypertension may promote Alzheimer’s disease pathology indirectly through intracranial atherosclerosis by limiting cerebral blood flow and/or dampening perivascular clearance. Similar indirect effects were observed for continuous measures of systolic and diastolic blood pressure. Within the overall sample and among Alzheimer’s dementia decedents, hypertension was indirectly associated with increased neuritic plaques and neurofibrillary tangles through its association with circle of Willis atherosclerosis. To examine the role of circle of Willis atherosclerosis in the association between hypertension and Alzheimer’s disease neuropathology, we analysed post-mortem neuropathological data on 2198 decedents from the National Alzheimer’s Coordinating Center database using joint simultaneous (i.e. Hypertension also promotes circle of Willis atherosclerosis, which contributes to cerebral hypoperfusion and arterial wall stiffening, two potential mechanisms linking hypertension to Alzheimer’s disease. Hypertension is common among older adults and is believed to increase susceptibility to Alzheimer’s disease, but mechanisms underlying this relationship are unclear. 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